In vitro activities of two new antifungal azoles
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چکیده
منابع مشابه
Antifungal azoles: old and new.
Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...
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Cent Eur J Urol 2013; 66: 200-201 DOI: 10.5173/ceju.2013.02.art22 Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a poorly–defined condition or a group of conditions in which chronic pain in the genital area and pain during prostate palpation are the two most common features. Causative treatment is rarely available since in most cases the etiology in unknown. Paradoxically, long–t...
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Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculation...
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In order to develop new approaches to treatment of infections due to Pseudallescheria boydii, the in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole, and fluconazole was studied. Combinations of amphotericin B and antifungal azoles were synergistic, additive, or indifferent in their interaction against P. boydii. Antagonism was not observed.
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Leishmaniasis, caused by protozoan parasites of the Leishmania genus, is one of the most prevalent neglected tropical diseases. It is endemic in 98 countries, causing considerable morbidity and mortality. Pentavalent antimonials are the first line of treatment for leishmaniasis except in India. In resistant cases, miltefosine, amphotericin B and pentamidine are used. These treatments are unsati...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1984
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.25.3.339